Advancing
life-changing treatments for eye disease 

Transforming ophthalmic care with durable therapies designed to improve vision

Eyconis is developing novel therapies to transform the lives of patients with eye disease

Serious eye diseases, such as wet age-related macular degeneration (wAMD) and diabetic macular edema (DME), are leading causes of vision loss worldwide. Available therapies require frequent injections to preserve vision, creating a substantial burden for patients, physicians, and caregivers.  When patients struggle to keep up with treatment, the result can be preventable, irreversible vision loss.


Eyconis, a clinical-stage biotechnology company, is advancing next-generation, long-acting ophthalmic therapeutics.  Through an exclusive worldwide license in ophthalmology from Ascendis Pharma (NASDAQ: ASND), Eyconis is utilizing the commercially validated TransCon® technology platform to develop therapies that have the potential to improve disease control and visual outcomes in people with serious eye disease.

Technology

TransCon® Technology Platform

The TransCon technology platform has been shown to enable sustained release of unmodified drug to optimize therapeutic effect, which has been validated via multiple approved products. The name derives from “transient conjugation” - the technology’s unique ability to transiently link an inert carrier to one or more drugs to achieve sustained release. TransCon therapies are designed with the goal of improving treatment efficacy and safety while reducing treatment burden.

TransCon therapies typically have three components: a drug, an inert carrier that shields the drug, and a linker that temporarily binds the drug and carrier. After administration, autocleavage of the linker occurs under physiologic conditions, allowing sustained release of the active, unmodified drug at a predictable rate, while the carrier and linker are naturally eliminated over time.

TransCon has been adapted for ophthalmology using biodegradable hyaluronic acid-based hydrogel microspheres optimized for delivery to the eye.

Drug

TransCon technology can be applied to a wide variety of therapeutics: antibodies, antibody fragments, proteins, peptides, small molecules, and more

TransCon Carrier

Insoluble carriers for
localized delivery

Soluble carriers for
systemic delivery

TransCon Linker

Linker families are designed for different parent drugs and release profiles

EYC-0305

A Foundational Anti-VEGF Therapy with Potential for Transformative Durability

EYC-0305 (TransCon aVEGF), our lead program, is an investigational therapy designed to provide long-acting drug exposure of an anti-VEGF antibody fragment (fAb) in the retina for six months or longer following a single standard intravitreal injection. This enables simple drug administration without the need for surgery, implants, or devices.

EYC-0305 is being evaluated in OVERTURE, an ongoing Phase 1b/2a clinical trial in treatment-naïve patients with wet age-related macular degeneration. The study is designed to evaluate intravitreal dosing of EYC-0305 once every 24 weeks for up to 
72 weeks.

Additional information is available at ClinicalTrials.gov under identifier NCT07587515

Pipeline

Advancing durable therapies for the treatment of serious eye diseases

Pre-Clinical

IND-Enabling

Clinical

EYC-0305
(TransCon aVEGF)

Wet AMD

Phase 1b/2a

Diabetic Macular Edema*

Phase 1b/2a

Diabetic Retinopathy*

Retinal Vein Occlusion*

*Will advance these indications into late-stage trials upon clinical POC in wet AMD

Pre-Clinical

IND-Enabling

Clinical

Undisclosed Candidates

Multiple Targets*

*Multiple biologically de-risked single-target and multi-target programs in pre-clinical development

Wet AMD: Wet Age-Related Macular Degeneration; POC: proof of concept

Team

Proven leaders in ophthalmology innovation

Our team combines deep ophthalmology expertise with proven experience in advancing novel therapies from science to patients

Mark Bachleda, PharmD, MBA

Chief Executive Officer

Emmett T. Cunningham, MD, PhD, MPH

Co-Founder & Executive Chairman of the Board

Oliver Stauch, PhD

Co-Founder & Chief Operating Officer

Robert L. Vitti, MD, MBA

Chief Medical Officer

Karen Chu, MS

Senior Vice President, Clinical Development and Operations

Benjamin Drosman, RPH, MBA

Senior Vice President, Regulatory

William Galush, PhD

Vice President, Analytical Development, Quality Control & Formulation

YongQi Mu, PhD

Vice President, Development Chemistry

Chris Heynes

Vice President, Process Development & Manufacturing

Rolf Jansen

Vice President, Operations & Project Management

Thomas Witt, MBA

Vice President, Business and Corporate Development

Jessica Harris, CPA

Head of Finance (Fractional)

Emmett T. Cunningham, MD, PhD, MPH

Co-Founder & Executive Chairman of the Board, Eyconis, Inc.

Daniel Estes, PhD

General Partner, Frazier Life Sciences

Jan Møller Mikkelsen

President & Chief Executive Officer, Ascendis Pharma A/S

Anna Chen, PhD

Partner, Frazier Life Sciences

Yvonne Yamanaka, PhD

Partner, venBio Partners

Garheng Kong, MD, PhD, MBA

Founding Managing Partner, HealthQuest Capital

Aaron Royston, MD, MBA

Board Observer, Managing Partner, venBio Partners

Mark Bachleda, PharmD, MBA

Chief Executive Officer, Eyconis, Inc.

Careers

If you are passionate about joining a team dedicated to delivering new therapeutic solutions to patients, please check the job openings link for our current opportunities.

Contact

Eyconis Inc.

1200 Bridge Parkway, Suite 200

Redwood City, CA 94065

866-EYCONIS (866-392-6647)

info@eyconis.com